Having talked to a few professionals and done a fair deal of research, somehow everything keeps pointing back to the Aprilia 250 chassis... It's the easiest fit, has the reputation to handle inhumanly good and having riddden one over the weekend I must agree. Not to mention that you can still get just about any exotic magnesium/titanium/carbon parts for them that simply bolt on and are in production.
As for the engine...it has to be RG. Lighter, sexier... And Nova racing makes it even sexier with a dry clutch kit!