Obviously you need to compare like to like, 21R to 28R, 21SP to 28SP.
Another question out to the forum....any difference between SE & SP barrels??
Then there are the 3 cylinder / piston pair matches, with cylinder sizes A, B + C corresponding to a specific piston size.
Honda UK online parts are saying the MC21SP B cylinder P/N has been superseded to / replaced by the MC28SP A cylinder, with no mention of availability of the MC28SP B cylinder.

I am currently trying to track down a brand new MC21SP B Cylinder (for spares). If the MC28SP B Cylinder has the same porting, OK, but I'm not happy about simply switiching to an A size cylinder, just when I've bought 2 X Top End Piston kits for a B Cylinder.
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Rich
MC21 Track Bike / RS250 NF5 'Spencer', NX5 'Cadalora' & NXA 'Aoyama' / RS500 / Two Brothers Racing RC30