Dana,

is this on a fresh rebuild? Crank, pistons, etc.? if so, I would run pre-mix. those first moments are important to have oil with your fuel. Also, is this a fresh oil pump and lines where it's not already filled with oil? if so, then again, yes, follow those instructions.

if the oil pump system was already in place and the lines are full, then chances are good you dont need to worry about it.